The crew arrives at their beautiful new vacation house in Savannah, Georgia; Lauren and Tiffany struggle to keep an explosive secret from Lyle, while Murray and Hannah must console Mattie.
Tiffany and Lauren tell Lyle devastating news about his fiancée, Santana; Walt attempts to woo a woman into bed by playing his guitar; Daddy brings the wrong girl home from the bar.
Murray wraps up his personal business in Mississippi and returns to the house to learn that the girls are still up in Lyle and Santana's relationship.
The house is divided when a secret comes out about Lyle's fiancée that Tiffany and Lauren have major issues with; Lyle is forced to make a decision that could change his life forever.
After healthy input from her roommates, Mattie makes a decision regarding her relationship with DJ; feeling like she's missing out, Hannah invites her boyfriend Cody to the house so she can get some lovin; too.
Lyle gets a shocking text from Santana; the gang goes ghost hunting and gets more than they bargained for; Mattie is forced to choose between her roommates and her family back home.
Wild Lyle returns when the gang decides to take a weekend vacation to a NASCAR race, but after some unexpected news about Santana, he goes off the deep end and lands in an ambulance, rushing to the hospital.
As Lyle spends time in the hospital, Mattie gives Santana a piece of her mind; Lauren flips her lid and the whole kitchen pays for it.
Lyle officially breaks it off with Santana over the phone; the crew bets on their Segway race--the boys versus girls, with the losers becoming their opponents' servants for a day; a newly-single Lyle rekindles old desires in Mattie.
Bubba surprises Tiffany with an unexpected visit, but Tiffany isn't sure how things will go after their recent arguments; after being rejected by numerous men at the bar, Hurricane Martha threatens the shores of Savannah.
The cast says goodbye to Savannah and to each other for the last time; old wounds open up between Tiffany and Bubba; Santana attempts to win back Lyle; the crew buries a time capsule in the backyard.
The Party Down South crew gets together one last time to share their favorite memories and reline their wildest moments from all five vacations together.