Drex catches his sort of girlfriend making out with a tattooed drug dealer at a party. Later, his roommate Matt finds Drex drowned, but alive in a bathtub. After getting hit by a bus and put into the morgue, Drex meets med student Cassie.
Drex explains the events of the previous evening to Cassie, and Matt makes plans to turn Drex's zombie life into an online phenomenon with his video camera.
Cassie offers Hypostatsis-Hematosis as an explanation for Drex's condition, and the search begins for Mystery Pill Guy (the tattooed drug dealer from the party).
Drex starts a new job and meets his weird cubicle neighbor Andy (Wayne Knight). He also receives an inter-office IM that asks him if he "woke up dead".
Drex arrives back home to Matt and Cassie, only to be fed calf brains by Matt as an experiment. Outside, we find that there's a van watching Drex's every move.
Drex, Cassie, and Matt go to the party house to search for the now infamous pill, which Cassie suspects may be a central nervous system depressant.
After running some tests, Cassie confirms that Drex's system is decaying, but not affecting him negatively. Back at work, the mysterious IMer starts messaging Drex again.
Drex finds that being a zombie gives him super skills. At work, however, Drex's new found powers challenge the reign of Andy, who pulls strings to have Drex subjected to drug test.
She could've been the one. Drex wimps out about meeting Debbie and so Cassie (Krysten Ritter) is sent to do the dirty work. While Matt (Josh Gad) cheers up Drex Cassie finds a clue about the mystery pill man. However, to use the new info Drex has to risk his new job.
The mystery pill man is revealed. Drex takes Matt and Cassie to see the man who gave him the little blue pill. One answer in this undead puzzle only leads to another, though.
Drex finds himself back in the hospital after taking a trip three stories straight down. He and Cassie discuss his relationship with Matt.
Drex wants to liven up his workspace with a picture of Cassie, but Andy freaks out. Possibly, he's the one who made that company policy. After the argument, Drex gets another IM from his Instant Message stalker.
Drex is on the hunt. When the mystery IM'er chats again Drex tracks them down goes to meet them, but it might be a trap.
Drex is out to find Pitsburgh666, the mystery IMer. Cassie and Matt are not going to let Drex walk into a trap alone. When the trio shows up at the spot they find something that both frightens and turns Matt on.
Drex gets distracted from his hunt for Pitsburgh66 when he meets an attractive fellow 'Zombie'.
Drex uses his new powers to track down W.U.D. girl, though she is proving hard to track. To find her Drex has to lie about his whereabouts to Cassie and Matt.
Drexis trapped by sexy WUD girl. This girl doesn't want to hurt Drex though instead she's got a offer for Drex that he shouldn't refuse. Meanwhile, Cassie and Matt are going crazy trying to find Drex.
Drex returns to Aurora, the WUD girl, to get answers. Meanwhile Matt and Cassie are left out of the loop.
Drex spends more time with Aurora and finds that he has more powers than he knew about.
Drex is becoming closer to Aurora and farther from Cassie, but she can keep an eye on him with Matt's variety of cameras.
After breaking into his office, Drex and Aurora have to find a way out after tripping the alarm.
After getting hit by a bus, Drex receives a visit from his mother, who has Drex's death certificate and an interesting secret.