Dr Kwane receives a frantic call from an old friend Justin about his cat UM. Genesis and Dr Kwane look at a little terrier Mamas who has been living on the streets of L.A with Desree for one year.
Dr Kwane comes across Bill and his dog Eli who has entropion and skin tumours. Dr Kwane and Genesis meets a young lady named Whitney and her dog Bummer, they are astounded to hear their unfortunate life story.
Dr Kwane comes across Andre and his 3-month old puppy Kuma, who needs to be vaccinated, neutered and trained. Dr Kwane meets Michael and his dog Presley, Michael is very concerned about a bump on Presley's neck.
Barbara needs to put her cockatoos into temporary boarding, but the required tests are very expensive so Dr Kwane helps. Dr Kwane meets James and his dog Ladybird, who has been limping on and off for the past few days.
Dr Kwane and Genesis meets a dachshund whose eyes are cloudy. Genesis helps Tank the dog, whose owners are worried about his recent weight loss. And the team meets Shadow the dog, who has been involved in a fight.
When Dr Kwane offers to give Goldie the dog a health check, the owner opens ups about how hard it is to live on the streets. While Kwane is on the search for a vet-technician to help him out.
Skid Row is home to the largest concentration of homeless in the USA. There Dr Kwane meets Walter and his dog Dinker, who has a very rare condition. Walter refuses surgery for Dinker but agrees to a management plan.
Dr Kwane meets Tammy and her dog and cat, who she loves so much that she feeds them before feeding herself. We meet Shay, his mother and their dog Shilo have been living in and out of their car for months. Shilo has a hernia.
After hearing a couple of people's stories, Genesis become emotionally overwhelmed. To cheer her up, they visit Charlie who runs a zoo/sanctuary that's home to 100 exotic rescue animals.
After booking surgery for a dog, Dr Kwane has no idea where to find him or his owner. At Venice Beach, Kwane and Genesis meet a man and his albino python. They then meet a kind-hearted couple and their dog Casanova.
Dr Kwane and Genesis meet a dog who can't put weight on his front leg, but the owner won't let them take him for x-rays. They then give a few dogs vaccine boosters. And Genesis adopts rescue puppy Pickles.
Dr Kwane helps Garrett and his dog Fruitloop who has been scooting around on her rear lately. They then visit a clinic run by volunteer vets and vet students that treats around 150 homeless pets in one day.