Yancy wins enough money playing poker to pay for his return home to New Orleans. The losing players decide to rob him of his winnings, but he escapes on a riverboat.
Yancy helps a sea captain who was cheated out of his money in a dive on notorious Gallatin Street.
City administrator Colton entrusts Yancy with an army payroll that is to be taken to Natchez on Yancy's riverboat, the Sultana, but robbers have other plans.
Yancy is relieved to find that a newspaper story about administrator Colton's death is premature, but fears that Colton will be the victim of trickery in an upcoming duel.
An Irish girl visitng New Orleans decides that Yancy is to be her future husband.
After administrator Colton hangs a member of an outlaw gang, the others decide to take revenge on his visiting sister.
A messenger is sent to New Orleans by a former general in the Civil War, but is killed before he can reveal what happened to a fortune that was taken from Richmond, Virginia.
A wealthy but lonely man who has come to New Orleans looking for a wife asks Yancy to help him.
An army officer with vengeance on his mind tries to stop a presidential pardon from reaching a man who is scheduled to die before a firing squad.
Shop owners receive threats of violence if they refuse to sell their property to three strangers.
Yancy tries to find out who's responsible for recent grave robberies.
Villains go after Yancy's dog after Yancy's father dies leaving a note that only the dog knows where the family pre-war fortune is buried.
Yancy and Pahoo are framed for a series of crimes, and now face execution.
A mysterious mad bomber steals explosives and threatens to blow up the entire city of New Orleans.
Yancy must deal with a female pirate whose gang has stolen a valuable necklace from representatives of the Mexican government.
Merchants are in such fear for their lives that Yancy gets no cooperation in his attempt to break a new protection racket.
A visiting Russian noble appears to have become a target for murder.
Yancy suspects foul play when a lottery winner dies before she can collect.
With a serial killer loose in New Orleans and the authorities seemingly powerless, a group of vigilantes decides to take action before any more prominent women are murdered.
A landowner comes up with a risky scheme to protect her property when it is threatened by flood waters.
Winning a half interest in a silver mine while visiting Virginia City, Yancy discovers that his new partner is a beautiful woman.
When famed General George Armstrong Custer visits New Orleans, Yancy discovers that he is being stalked by an Indian seeking revenge for a past wrong.
Yancy decides to help a fellow riverboat owner whose fleet is being sabotaged by rivals trying to corner the market on river traffic.
Yancy is arrested on a charge of high treason. His crime: selling John Wilkes Booth the gun that killed President Abraham Lincoln. While Derringer is held in solitary confinement, his friends must refute forged evidence and find where the his matched set of pistols, the ones alleged purchased by Booth, were hidden when renegades ransacked his plantation during the Civil War.
To assist a woman in her crusade to provide a home for the city's orphans, Yancy comes up with a scheme that requires the aid of photography pioneer Matthew Brady.
Yancy's Indian friend Pahoo becomes an important element in efforts to prevent a war with the Pawnee tribes.
Yancy is sentenced to hang for killing a man in a duel.
Trying to stop some gun smugglers, Yancy has a run-in with a boxing champion and a re-match with a female river pirate.
With the city of New Orleans plagued by counterfeit money, General Hugh Morgan arrives in New Orleans with orders promoting John Colton to a post in Washington and giving Morgan command of the city.
Yancy is at a loss to figure out what's going on when a marshal he knows charges an old wartime friend with murder.
Yancy tries to combat superstition when the city is terrorized by a mysterious voodoo priestess.
Yancy's good friend, Miss Mandarin, is accused of smuggling opium into the city inside firecrackers.
A friend of Yancy's comes to visit from Virginia City, with news that his silver mine is doing well, but that there is a gravestone in the cemetery with Yancy's name on it.
On a train trip to a celebration of the completion of the transcontinental railroad, Yancy discovers a saboteur.