An unsophisticated young woman from the Mississippi swamps falls in love with an unconventional southern gentleman.

Tammy leaves the river in Mississippi to attend college, developing a relationship with Tom Freeman (John Gavin). Sandra Dee replaces Debbie Reynolds in this and the third Tammy movie. This film introduces both a new theme song, "Tammy Tell Me True", and the character of Mrs. Annie Call, played by veteran Beulah Bondi. Mrs. Call ultimately moves in with Tammy at the Ellen B. and would be the catalyst for the events in the following film, "Tammy and The Doctor".

Tammy becomes a nurse's aide, works in a hospital, cares for an old rich woman, and causes romantic commotion in the life of Dr. Mark Cheswick.

A bayou girl (Debbie Watson) and her kin (Frank McGrath, Denver Pyle) have run-ins with some rich folks.