A pretty young Mexican girl returns to her hometown to make funeral arrangements for her beloved aunt, who has just died. Soon she begins to hear disturbing stories about the town being infested by vampires, and she eventually begins to suspect that her remaining aunt and the mysterious next-door neighbor may be involved.

In Sierra Negra, graverobbers Barraza and Mendoza steal the coffin of Count Karol de Lavud, before heading to a hospital. Barraza sees a medallion upon the coffin's opening and demands more money from Mendoza. Meanwhile, Marta González, recovering from traumatic events, works as a nurse with Dr. Saldívar. When Barraza removes the wooden stake in order to steal Lavud's medallion, the vampire returns to life and begins a crime spree, hunting down Marta to marry her.