After an affair with the fabled Snake King, a woman gives birth to a son she names Veasna. After Veasna finds a wife, a witch curses their daughter to be born with snakes instead of hair.

Angered by the constant bad luck that has befallen her family, the Snake Girl decides that enough is enough and uses her curse to take revenge on her enemies.

In a small village, Nhi comes across a Snake Immortal and falls in love with him. She becomes pregnant by the snake, but does not tell her husband. When he discovers the truth, he kills both Nhi and the Snake Immortal. One of the small snakes escapes from Nhi's abdomen, and is brought up by another immortal. Slowly the snake grows up to be a beautiful woman, who sets out to develop another relationship.