Flo is not quite a normal teenager: While all his friends only think about sex he can't even pronounce the word "S - E - X". But everything changes completely when one morning Flo wakes up from a strange call. His penis, excited for the first time, begins to talk to him. He claims that Flo severely neglected him for 15 years and it's time to release him.

In the sequel of "Ants in the Pants" we again meet Flo and his friends.

Teenagers Charly and Paula worry that sex could ruin their friendship, while their suddenly and surprisingly bossy private parts urge them to go for it.