Panji Tengkorak tells the story of Panji, a master in the dark arts of silat (Indonesian martial art), who is searching for the person who had killed his wife. In his journey, Panji always disguises himself as a beggar and wears a skull mask. Even though he looked cruel, Panji is a good and loyal man.

Masked vigilante Panji Tengkorak (Sutomo) helps two sisters get revenge on the gang who killed their master.